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Secretory breast carcinoma with metastatic sentinel lymph node

Identifieur interne : 007855 ( Main/Exploration ); précédent : 007854; suivant : 007856

Secretory breast carcinoma with metastatic sentinel lymph node

Auteurs : Salvatore Vieni [Italie] ; Daniela Cabibi [Italie] ; Calogero Cipolla [Italie] ; Salvatore Fricano [Italie] ; Giuseppa Graceffa [Italie] ; Mario Adelfio Latteri [Italie]

Source :

RBID : PMC:1764883

Abstract

Background

Secretory mammary carcinoma is a rare breast neoplasia originally described in children but sometimes also found in adults. It presents a more favourable outcome than more common histological types of breast carcinoma; published literature in fact reports only a few cases with axillary lymph node metastases and only four cases with distant metastases.

Clinical presentation

In this paper we report a rare case of secretory breast carcinoma with axillary lymph node metastases in a 33-year-old woman. To our knowledge, this is the first case of secretory carcinoma involving biopsy of the sentinel lymph node and investigation of the e-cadherin expression.

We found positivity for e-cadherin, which would support the hypothesis that this type of tumour is a variant of the infiltrating ductal carcinoma.

Conclusion

After a careful analysis of reported data, we have come to the conclusion that the treatment of choice for patients with secretory breast carcinoma should be conservative surgery with sentinel lymph node biopsy, followed by accurate follow-up. We are of the opinion that while post-operative radiotherapy is indicated in adult patients who have undergone quadrantectomy, it should not be used in children. Although several cases of secretory carcinoma have been treated with adjuvant chemotherapy, there are still no reliable data regarding the real value of such a choice.


Url:
DOI: 10.1186/1477-7819-4-88
PubMed: 17150092
PubMed Central: 1764883


Affiliations:


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<p>In this paper we report a rare case of secretory breast carcinoma with axillary lymph node metastases in a 33-year-old woman. To our knowledge, this is the first case of secretory carcinoma involving biopsy of the sentinel lymph node and investigation of the e-cadherin expression.</p>
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<p>After a careful analysis of reported data, we have come to the conclusion that the treatment of choice for patients with secretory breast carcinoma should be conservative surgery with sentinel lymph node biopsy, followed by accurate follow-up. We are of the opinion that while post-operative radiotherapy is indicated in adult patients who have undergone quadrantectomy, it should not be used in children. Although several cases of secretory carcinoma have been treated with adjuvant chemotherapy, there are still no reliable data regarding the real value of such a choice.</p>
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